D-青霉胺代谢概述。
An outline of D-penicillamine metabolism.
作者信息
Perrett D
机构信息
Medical Unit, Dunn Laboratories, St Bartholomew's Hospital, London.
出版信息
Proc R Soc Med. 1977;70 Suppl 3(Suppl 3):61-4. doi: 10.1177/00359157770700S321.
Abstract
In a study using 14C-D-penicillamine in a normal subject only 50% of the D-penicillamine was absorbed from the gut. The major urinary metabolites are cysteine-penicillamine and penicillamine disulphide. S-methyl-D-penicillamine is the only biochemically transformed metabolite so far identified.
摘要
在一项针对正常受试者使用14C-D-青霉胺的研究中，只有50%的D-青霉胺从肠道吸收。主要的尿液代谢产物是半胱氨酸-青霉胺和青霉胺二硫化物。S-甲基-D-青霉胺是目前已鉴定出的唯一经过生物化学转化的代谢产物。
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本文引用的文献
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CYSTINURIA: EFFECT OF D-PENICILLAMINE ON PLASMA AND URINARY CYSTINE CONCENTRATIONS.胱氨酸尿症：D-青霉胺对血浆和尿液胱氨酸浓度的影响
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Effect of penicillamine on cystinuria.青霉胺对胱氨酸尿症的影响。
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Transport of penicillamine across mucosa of the rat small intestine in vitro.青霉胺在大鼠小肠黏膜的体外转运
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Studies with 35S-labelled DL-penicillamine in patients with Wilson's disease.对威尔逊病患者进行的35S标记的DL-青霉胺研究。
Q J Med. 1971 Apr;40(158):275-87. doi: 10.1093/oxfordjournals.qjmed.a067270.
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[Pharmacokinetic studies on 14 C-labelled penicillamine].
Arzneimittelforschung. 1972 Sep;22(9):1426-33.
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[Pharmacokinetics and metabolism of D- and L-penicillamine. 1. Blood level, transport and protein binding].[D-青霉胺和L-青霉胺的药代动力学与代谢。1. 血药浓度、转运及蛋白结合]
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