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[胸腺衬里对胚胎小鼠肝脏悬液中造血干细胞动力学的影响]

[Effect of the lining of the thymus gland on hematopoietic stem cell kinetics in a suspension of embryonic mouse liver].

作者信息

Manakova T E

出版信息

Biull Eksp Biol Med. 1975 May;79(5):97-9.

PMID:1227601
Abstract

A study was made of the kinetics of hemopoietic stem cells in the organic culture of a suspension of mouse embryonic liver cultivated directly on the filters and on the preliminarily grown embryonic thymic feeder. It was shown that stem hemopoietic cells were retained in the course of one month of cultivation in the embryonic liver suspensions; during the first two weeks hemopoiesis in the suspension practically failed to differ from such in the fragments of the same age and cultivation period, whereas during the subsequent periods hemopoiesis proved to be more active in the suspension cultivated on thymic feeder. A possible participation of the thymus in the hemopoiesis is discussed.

摘要

对直接培养在滤器上以及预先培养的胚胎胸腺饲养层上的小鼠胚胎肝脏悬液有机培养中的造血干细胞动力学进行了研究。结果表明,造血干细胞在胚胎肝脏悬液培养一个月的过程中得以保留;在前两周,悬液中的造血过程与相同年龄和培养期的组织碎片中的造血过程实际上并无差异,而在随后的时期,在胸腺饲养层上培养的悬液中的造血过程更为活跃。文中讨论了胸腺在造血过程中可能的参与情况。

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