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[胸腺衬里对胚胎小鼠肝脏悬液中造血干细胞动力学的影响]

[Effect of the lining of the thymus gland on hematopoietic stem cell kinetics in a suspension of embryonic mouse liver].

作者信息

Manakova T E

出版信息

Biull Eksp Biol Med. 1975 May;79(5):97-9.

PMID:1227601
Abstract

A study was made of the kinetics of hemopoietic stem cells in the organic culture of a suspension of mouse embryonic liver cultivated directly on the filters and on the preliminarily grown embryonic thymic feeder. It was shown that stem hemopoietic cells were retained in the course of one month of cultivation in the embryonic liver suspensions; during the first two weeks hemopoiesis in the suspension practically failed to differ from such in the fragments of the same age and cultivation period, whereas during the subsequent periods hemopoiesis proved to be more active in the suspension cultivated on thymic feeder. A possible participation of the thymus in the hemopoiesis is discussed.

摘要

对直接培养在滤器上以及预先培养的胚胎胸腺饲养层上的小鼠胚胎肝脏悬液有机培养中的造血干细胞动力学进行了研究。结果表明,造血干细胞在胚胎肝脏悬液培养一个月的过程中得以保留;在前两周,悬液中的造血过程与相同年龄和培养期的组织碎片中的造血过程实际上并无差异,而在随后的时期,在胸腺饲养层上培养的悬液中的造血过程更为活跃。文中讨论了胸腺在造血过程中可能的参与情况。

相似文献

1
[Effect of the lining of the thymus gland on hematopoietic stem cell kinetics in a suspension of embryonic mouse liver].[胸腺衬里对胚胎小鼠肝脏悬液中造血干细胞动力学的影响]
Biull Eksp Biol Med. 1975 May;79(5):97-9.
2
[Effect of mouse age on the ability of hematopoietic stem cells to interact with thymus cells].[小鼠年龄对造血干细胞与胸腺细胞相互作用能力的影响]
Ontogenez. 1978;9(4):376-81.
3
Thymic microenvironmental factor: a possible chemoattractant for hemopoietic stem cells.
Thymus. 1985;7(6):345-56.
4
[Protective potential of hematopoietic cells of the embryonic liver during long-term culture].[长期培养过程中胚胎肝脏造血细胞的保护潜力]
Biull Eksp Biol Med. 1987 Jul;104(7):93-6.
5
[Relationship between hematopoietic stem differentiation and the functional state of the thymus].[造血干细胞分化与胸腺功能状态之间的关系]
Ontogenez. 1978;9(4):406-11.
6
[Effect of the thymus on hematopoietic stem cells and on their capacity for self-maintenance].胸腺对造血干细胞及其自我维持能力的影响
Biull Eksp Biol Med. 1979 Jun;87(6):610-2.
7
Embryonic mouse thymus development: stem cell entry and differentiation.胚胎小鼠胸腺发育:干细胞的进入与分化
Immunology. 1978 Jan;34(1):69-75.
8
[In vitro production of hemopoietic stem cells: washings from organ cultures of embryonic liver].
Biull Eksp Biol Med. 1979 Mar;87(3):281-2.
9
Effect of age on the proportion of mouse bone marrow cells migrating in response to newborn thymus supernatant. Cell migration and thymus evolution in mice.年龄对响应新生胸腺上清液迁移的小鼠骨髓细胞比例的影响。小鼠的细胞迁移与胸腺发育
Thymus. 1991 Dec;18(4):237-41.
10
Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.受辐照小鼠胸腺叶中造血干细胞的分化。子代的动力学和表型。
J Immunol. 1990 Dec 1;145(11):3661-8.