Field T D, Rosenstock J, King E C, Greene E
Department of Psychology, University of Southern California, Los Angeles 90007.
Brain Res Bull. 1978 Sep-Oct;3(5):451-6. doi: 10.1016/0361-9230(78)90074-6.
The present study examined the effects of lesions of the mammillary system on spatial memory and arousal. Destruction of the medial mammillary nucleus or the mammillotegmental tract produces impairments on a delayed alternation task and greatly increases activity in the open-field. Lesions of the mammillothalamic tract produce a differential effect in that the spatial alternation deficit is accompanied by a general lethargy and unresponsiveness. It is suggested that the mammillary system plays a crucial role in the short-term storage of proprioceptive information necessary for the successive execution of maze choices. It also appears to play a role in the arousal state of the animal.
本研究考察了乳头体系统损伤对空间记忆和觉醒的影响。内侧乳头核或乳头体被盖束的破坏会导致延迟交替任务受损，并显著增加旷场中的活动。乳头丘脑束的损伤产生了不同的效应，即空间交替缺陷伴随着普遍的嗜睡和无反应性。有人提出，乳头体系统在迷宫选择连续执行所需的本体感觉信息的短期存储中起关键作用。它似乎也在动物的觉醒状态中发挥作用。
