• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乳头体中用于位置和物体识别记忆的细胞类型特异性回路。

Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory.

作者信息

Li Lanfang, Guo Yiqing, Jing Wei, Tang Xiaomei, Zeng Jinyu, Hou Zhenye, Song Yige, He Aodi, Li Hao, Zhu Ling-Qiang, Lu Youming, Li Xinyan

机构信息

Wuhan Center of Brain Science, Huazhong University of Science and Technology, Wuhan, 430030, China.

Innovation Center of Brain Medical Sciences, Ministry of Education of the People's Republic of China, Wuhan, 430030, China.

出版信息

Adv Sci (Weinh). 2025 Apr;12(13):e2409397. doi: 10.1002/advs.202409397. Epub 2025 Feb 10.

DOI:10.1002/advs.202409397
PMID:39928529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11967786/
Abstract

Mammillary body (MB) is traditionally viewed as a structural node of an anatomic circuit for emotion and memory. However, little is known about its molecular and cellular organizations. Here, a discovery that MB contains four subtypes of neurons that occupy different spatial subregions is reported. Of these, two subtypes of neurons are tagged by parvalbumin (PV) and dopamine receptor-D2 (Drd2) markers. PV neurons are spontaneously active, whereas Drd2 neurons are inactive at rest and generate rebound bursts. These two distinct electrophysiological properties are encoded by Kcnn4 and Cacna1h. PV and Drd2 neurons generate two distinct cell-type specific circuits by receiving inputs from two discrete subiculum neuronal classes. Gain- and loss-of-function studies on these cortical-subcortical circuits demonstrate their differential roles for place and object recognition memory. This finding provides a comprehensive molecular and structural atlas of MB neurons at single-cell resolution and reveals that MB contains molecularly, structurally, and functionally dissociable streams within its serial architecture.

摘要

乳头体（MB）传统上被视为情感和记忆解剖回路的一个结构节点。然而，人们对其分子和细胞组织知之甚少。在此，报告了一项发现，即乳头体包含占据不同空间亚区域的四种神经元亚型。其中，两种神经元亚型由小白蛋白（PV）和多巴胺受体D2（Drd2）标记物标记。PV神经元自发活动，而Drd2神经元在静息时不活动并产生反弹爆发。这两种不同的电生理特性由Kcnn4和Cacna1h编码。PV和Drd2神经元通过接收来自两个离散的海马下托神经元类别的输入，产生两种不同的细胞类型特异性回路。对这些皮质-皮质下回路的功能获得和功能丧失研究表明，它们在位置和物体识别记忆中具有不同的作用。这一发现提供了单细胞分辨率下乳头体神经元的全面分子和结构图谱，并揭示乳头体在其串联结构中包含分子、结构和功能上可分离的信息流。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/3f13f32b9e4a/ADVS-12-2409397-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/d2f7bb29043f/ADVS-12-2409397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/ab240bc638d9/ADVS-12-2409397-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/68a5440c4004/ADVS-12-2409397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/26e904717f7f/ADVS-12-2409397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/95aff30afd6a/ADVS-12-2409397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/36fb8adea008/ADVS-12-2409397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/3f13f32b9e4a/ADVS-12-2409397-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/d2f7bb29043f/ADVS-12-2409397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/ab240bc638d9/ADVS-12-2409397-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/68a5440c4004/ADVS-12-2409397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/26e904717f7f/ADVS-12-2409397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/95aff30afd6a/ADVS-12-2409397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/36fb8adea008/ADVS-12-2409397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/11967786/3f13f32b9e4a/ADVS-12-2409397-g004.jpg

相似文献

1
Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory.乳头体中用于位置和物体识别记忆的细胞类型特异性回路。
Adv Sci (Weinh). 2025 Apr;12(13):e2409397. doi: 10.1002/advs.202409397. Epub 2025 Feb 10.
2
How do mammillary body inputs contribute to anterior thalamic function?乳头体输入如何影响丘脑前核功能？
Neurosci Biobehav Rev. 2015 Jul;54:108-19. doi: 10.1016/j.neubiorev.2014.07.025. Epub 2014 Aug 11.
3
Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease.在阿尔茨海默病中，小鼠大脑中的外侧乳状体神经元易受到不成比例的影响。
Sci Transl Med. 2023 Apr 19;15(692):eabq1019. doi: 10.1126/scitranslmed.abq1019.
4
Electrophysiology of the mammillary complex in vitro. II. Medial mammillary neurons.体外乳头复合体的电生理学。II. 内侧乳头神经元。
J Neurophysiol. 1992 Oct;68(4):1321-31. doi: 10.1152/jn.1992.68.4.1321.
5
Characterization of neurons of the supramammillary nucleus and mammillary body that discharge rhythmically with the hippocampal theta rhythm in the rat.大鼠中与海马θ节律同步节律性放电的乳头体上核和乳头体神经元的特征
J Neurosci. 1994 Nov;14(11 Pt 2):7040-52. doi: 10.1523/JNEUROSCI.14-11-07040.1994.
6
The effects of fornix transection and combined fornix transection, mammillary body lesions and hippocampal ablations on object-pair association memory in the rhesus monkey.穹窿横切术、联合穹窿横切术、乳头体损伤及海马切除对恒河猴物体配对联想记忆的影响。
Behav Brain Res. 1989 Nov 1;35(2):85-94. doi: 10.1016/s0166-4328(89)80109-3.
7
The mammillary bodies and memory: more than a hippocampal relay.乳头体与记忆：不止是海马体的中继站。
Prog Brain Res. 2015;219:163-85. doi: 10.1016/bs.pbr.2015.03.006. Epub 2015 May 16.
8
Phase relations of rhythmic neuronal firing in the supramammillary nucleus and mammillary body to the hippocampal theta activity in urethane anesthetized rats.在乌拉坦麻醉大鼠中，乳头体上核和乳头体内节律性神经元放电与海马θ活动的相位关系。
Hippocampus. 1997;7(2):204-14. doi: 10.1002/(SICI)1098-1063(1997)7:2<204::AID-HIPO7>3.0.CO;2-M.
9
Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology.精神分裂症患者乳头体中小清蛋白免疫反应性投射神经元数量显著减少：边缘系统神经病理学的进一步证据
Ann N Y Acad Sci. 2007 Jan;1096:120-7. doi: 10.1196/annals.1397.077.
10
Separate cortical and hippocampal cell populations target the rat nucleus reuniens and mammillary bodies.分离的皮质和海马细胞群体靶向大鼠穹窿联合核和乳头体。
Eur J Neurosci. 2019 Jun;49(12):1649-1672. doi: 10.1111/ejn.14341. Epub 2019 Feb 21.

本文引用的文献

1
Physiological characteristics of neurons in the mammillary bodies align with topographical organization of subicular inputs.乳状体神经元的生理特征与内嗅皮质输入的拓扑组织相一致。
Cell Rep. 2024 Aug 27;43(8):114539. doi: 10.1016/j.celrep.2024.114539. Epub 2024 Jul 23.
2
Obesogenic diet induces circuit-specific memory deficits in mice.致肥胖饮食会诱发小鼠特定脑回路的记忆缺陷。
Elife. 2024 Mar 4;13:e80388. doi: 10.7554/eLife.80388.
3
Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease.
在阿尔茨海默病中，小鼠大脑中的外侧乳状体神经元易受到不成比例的影响。
Sci Transl Med. 2023 Apr 19;15(692):eabq1019. doi: 10.1126/scitranslmed.abq1019.
4
Molecularly defined and functionally distinct cholinergic subnetworks.分子定义且功能各异的胆碱能子网络。
Neuron. 2022 Nov 16;110(22):3774-3788.e7. doi: 10.1016/j.neuron.2022.08.025. Epub 2022 Sep 20.
5
Neuronal circuitry for recognition memory of object and place in rodent models.啮齿类动物模型中对物体和位置识别记忆的神经元回路。
Neurosci Biobehav Rev. 2022 Oct;141:104855. doi: 10.1016/j.neubiorev.2022.104855. Epub 2022 Sep 8.
6
Thalamo-hippocampal pathway regulates incidental memory capacity in mice.丘脑-海马通路调节小鼠的情景记忆能力。
Nat Commun. 2022 Jul 20;13(1):4194. doi: 10.1038/s41467-022-31781-8.
7
Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes.在雷特综合征年轻雌性小鼠模型中进行米氮平治疗，确定了挽救早期表型的时间窗。
Exp Neurol. 2022 Jul;353:114056. doi: 10.1016/j.expneurol.2022.114056. Epub 2022 Mar 28.
8
VGLUT3 neurons in median raphe control the efficacy of spatial memory retrieval via ETV4 regulation of VGLUT3 transcription.中缝背核中的 VGLUT3 神经元通过 ETV4 调节 VGLUT3 转录来控制空间记忆检索的效率。
Sci China Life Sci. 2022 Aug;65(8):1590-1607. doi: 10.1007/s11427-021-2047-8. Epub 2022 Jan 20.
9
A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h.COCH 神经元回路通过 MTF1 对 Cacna1h 的激活来编码社交应激诱导的焦虑。
Cell Rep. 2021 Dec 28;37(13):110177. doi: 10.1016/j.celrep.2021.110177.
10
Robust information routing by dorsal subiculum neurons.背侧海马下托神经元的强大信息传递
Sci Adv. 2021 Mar 10;7(11). doi: 10.1126/sciadv.abf1913. Print 2021 Mar.