Scharp D W, Murphy J J, Newton W T, Ballinger W F, Lacy P E
Surgery. 1975 Jan;77(1):100-5.
Islets of Langerhans from unrelated donor rhesus monkeys were transplanted into the portal vein of five rhesus monkeys which had been made diabetic by partial pancreatectomy and Streptozotocin. There was definite improvement of the diabetic state with an increase in the mean KT1/2 from 0.71 to 1.52 percent per minute. The islets were isolated by a more efficient digestion-filtration process than previously had been described. This process has allowed, for the first time, successful isolation of large masses of islets permitting islet transplants in subhuman primates.
将来自无关供体恒河猴的胰岛移植到五只经部分胰腺切除术和链脲佐菌素诱导成糖尿病的恒河猴的门静脉中。糖尿病状态有明显改善，平均 KT1/2 从每分钟 0.71% 增加到 1.52%。胰岛通过一种比先前描述的更有效的消化 - 过滤方法分离。这一方法首次成功分离出大量胰岛，从而能够在非人灵长类动物中进行胰岛移植。
