Oster H, Olsen D B, Jarvik R, Stanley T H, Volder J G, Kolff W J
Surgery. 1975 Jan;77(1):113-7.
This is a report of an experiment wherein a calf had its natural heart replaced with an artificial heart and survived for 18 days and 20 hours. All measured physiologic parameters remained normal until the fourteenth day. Thereafter a gradual persistent rise in venous pressure and signs of a decreased cardiac output occurred. However, the animal outwardly appeared normal until the eighteenth day. During the nineteenth day it became comatose and was killed. At autopsy large thrombi were found in both atria, impairing ventricular filling, resulting in venous congestion and diminished cardiac output. This extended survival time and our ability to understand and eliminate the problems associated with artificial heart implantation give support to our hope that artificial hearts for man will be possible in the not too distant future.
这是一份关于一项实验的报告，在该实验中，一头小牛的天然心脏被人工心脏所取代，并存活了18天20小时。在第14天之前，所有测量的生理参数均保持正常。此后，静脉压逐渐持续升高，出现心输出量下降的迹象。然而，这头动物在第18天之前外表看起来都正常。在第19天，它陷入昏迷并被处死。尸检时发现两个心房都有大血栓，影响心室充盈，导致静脉淤血和心输出量减少。这种延长的存活时间以及我们理解和消除与人工心脏植入相关问题的能力，支持了我们的希望，即在不太遥远的将来，为人类制造人工心脏将成为可能。
