Lawson J, Olsen D B, Kolff W J, Liu W H, Hershgold E J, Van Kampen K
J Lab Clin Med. 1976 May;87(5):848-58.
An artificial heart constructed from Biomer, a polyurethane, kept a calf alive for more than three months after its natural heart was removed. During this time all of the calf's vital organs apparently functioned well. We had been able to keep similar animals alive with Jarvik III hearts made from Silastic for one month. The principal problem encountered was the infection centering along the compressed air drive lines to the artificial heart. Another problem is thrombus formation in the artificial heart. Redesigning of the artificial ventricles to improve flow patterns and reduce material discontinuities should be attempted to eliminate localized thrombus formation within the ventricles. The rapid growth of the calf has led us to examine the possibility of alternative animal models for future long-term experiments. The most encouraging aspects of this experiment were the long survival time of the calf and the very low level of blood damage caused by the artificial heart.
用聚氨酯材料Biomer制成的人造心脏，在小牛的天然心脏被摘除后，使其存活了三个多月。在此期间，小牛的所有重要器官显然都功能良好。我们曾用硅橡胶制成的Jarvik III型心脏让类似的动物存活了一个月。遇到的主要问题是围绕通向人造心脏的压缩空气驱动管发生感染。另一个问题是人造心脏内形成血栓。应尝试重新设计人造心室以改善血流模式并减少材料不连续性，从而消除心室内局部血栓的形成。小牛的快速生长促使我们研究未来长期实验采用替代动物模型的可能性。该实验最令人鼓舞的方面是小牛的长时间存活以及人造心脏造成的血液损伤程度极低。
