[The effect of epiphysectomy on the concentration of aldosterone, corticosterone and transcortin in the peripheral blood].

Experiments were conducted on female Wistar rats, weighing 120-130 g. Epiphysis in rats was removed 3 weeks before the principal experiment. Aldosterone was determined in the peripheral blood by the radioimmunological method, corticosteron--spectrophotometrically, binding capacity of transcortin, free, bound and sum-total 11-OCS--by the method of gel filtration in biogel. In intact rats at the phase of metaestrus aldosterone content in the peripheral blood constituted 45.2 +/- 4.62 ng/100 ml. Epiphysectomy produced a reduction of aldosterone content (32.4 +/- 3.69 ng/100 ml) and an elevation of corticosterone level and of transcortin binding capacity in the female rats.