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[类固醇-皮质素结合平衡常数对兔体内皮质醇和皮质酮代谢清除率的影响]

[Effect of the equilibrium constant of steroid-transcortin binding on the metabolic clearance rate of cortisol and corticosterone in the rabbit].

作者信息

Daniel J Y, Assenmacher I

出版信息

C R Seances Acad Sci D. 1980 Jun 16;290(22):1425-30.

PMID:6772332
Abstract

In the Rabbit the metabolic clearance rate (MCR) was shown to be eightfold greater for corticosterone than for cortisol. This marked difference in the clearance kinetics of both glucocorticosteroids appears to result from a difference in the affinity of transcortin (CBG) towards both hormones, since the maximal association constant of CBG was twice as high for cortisol as for corticosterone.

摘要

在兔子身上，皮质酮的代谢清除率（MCR）比皮质醇高八倍。这两种糖皮质激素清除动力学的显著差异似乎源于皮质素转运蛋白（CBG）对这两种激素亲和力的差异，因为CBG对皮质醇的最大结合常数是皮质酮的两倍。

相似文献

1
[Effect of the equilibrium constant of steroid-transcortin binding on the metabolic clearance rate of cortisol and corticosterone in the rabbit].[类固醇-皮质素结合平衡常数对兔体内皮质醇和皮质酮代谢清除率的影响]
C R Seances Acad Sci D. 1980 Jun 16;290(22):1425-30.
2
Interrelations between binding affinity and metabolic clearance rate for the main corticosteroids in the rabbit.兔体内主要皮质类固醇结合亲和力与代谢清除率之间的相互关系。
J Steroid Biochem. 1982 Mar;16(3):379-84. doi: 10.1016/0022-4731(82)90049-8.
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Increased plasma protein binding and lower metabolic clearance rate of aldosterone in plasma of low cortisol concentration.在低皮质醇浓度血浆中，醛固酮的血浆蛋白结合增加且代谢清除率降低。
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Gen Comp Endocrinol. 2001 Apr;122(1):67-77. doi: 10.1006/gcen.2001.7613.
5
Effects of neurotrophic stress on maternal metabolism and binding of plasma cortisol in late pregnant guinea-pigs and their fetuses.神经营养应激对妊娠晚期豚鼠及其胎儿母体代谢和血浆皮质醇结合的影响。
J Dev Physiol. 1990 Jan;13(1):13-6.
6
Serum inflammatory responses of transcortin binding activities and of total and free corticosterone and progesterone levels in developing rats: a kinetic approach.发育中大鼠皮质素结合活性以及总皮质酮和游离皮质酮与孕酮水平的血清炎症反应：一种动力学方法。
Int J Tissue React. 1985;7(6):443-8.
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[Binding ability of rat transcortin after adrenalectomy].[大鼠肾上腺切除术后皮质转运蛋白的结合能力]
Vopr Med Khim. 1991 Mar-Apr;37(2):34-7.
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Distribution of 18-hydroxycorticosterone between red blood cells and plasma.18-羟皮质酮在红细胞与血浆之间的分布。
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Distinct specificity for corticosteroid binding sites in amphibian cytosol, neuronal membranes, and plasma.对两栖动物细胞质、神经元膜和血浆中皮质类固醇结合位点的独特特异性。
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A nonlabeled method to evaluate cortisol production rate by modeling plasma CBG-free cortisol disposition.一种通过模拟血浆游离皮质醇结合球蛋白（CBG）的皮质醇代谢来评估皮质醇生成率的非标记方法。
Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E946-56. doi: 10.1152/ajpendo.2001.281.5.E946.