[Effect of the equilibrium constant of steroid-transcortin binding on the metabolic clearance rate of cortisol and corticosterone in the rabbit].

In the Rabbit the metabolic clearance rate (MCR) was shown to be eightfold greater for corticosterone than for cortisol. This marked difference in the clearance kinetics of both glucocorticosteroids appears to result from a difference in the affinity of transcortin (CBG) towards both hormones, since the maximal association constant of CBG was twice as high for cortisol as for corticosterone.