Bélanger L F, Guertin-Coutu L, Parton D E
Rev Can Biol. 1975 Dec;34(4):195-203.
Dietary magnesium deficiency has been more damaging to the mast cells in females than in males. Estradiol at a dose of 1.5 mg per week for 4 weeks and testosterone at a dose of 3 mg per week in the males have resulted in lesser mast cell depletion in the magnesium-deficient animals. Large doses of testosterone have also improved in the condition of the skin, decreased the severity of other magnesium deprivation symptoms such as nephrocalcinosis, bone hyperplasia and nervous manifestations in the males. Testosterone has had no beneficial effect on mast cells of the females but the large dose has protected the kidney against nephrocalcinosis. Estrogen administration has aggrevated the production of kidney stones in the females.
饮食中镁缺乏对雌性肥大细胞的损害比对雄性更大。每周1.5毫克，持续4周的雌二醇以及雄性每周3毫克的睾酮，使缺镁动物的肥大细胞减少程度较轻。大剂量睾酮还改善了雄性的皮肤状况，减轻了其他镁缺乏症状的严重程度，如肾钙质沉着、骨质增生和神经表现。睾酮对雌性肥大细胞没有有益作用，但大剂量可保护肾脏免受肾钙质沉着的影响。给予雌激素会加重雌性肾结石的形成。
