Van Kruiningen H J
Vet Pathol. 1975;12(5-6):446-59. doi: 10.1177/0300985875012005-00611.
Thirteen cases of granulomatous colitis of Boxer dogs were studied by electron microscopy to define the contents of macrophages and to seek infectious agents. Macrophages were of three types. The most numerous were distended with residual bodies composed of membranes and parallel pairs of membranes, many arranged in circular patterns. A second common form had heterogeneous cytoplasm distended with phagosomes containing numerous small granular spheres of various sizes and electron densities. The least common were "young" macrophages containing phagocytic vacuoles. Rare macrophages in four of 13 dogs contained bacteria. Macrophages in five of the dogs contained abundant coccoid, coccobacillary of lobulated granular structures, 100-500 nm in diameter, resembling chlamydia. Transition from phagocytic particle to phagosome to residual body was apparent. Granulomatous colitis of Boxer dogs is probably caused by a lipid-rich, ribosome-rich, coccoid to coccobacillary organism that possesses a cell membrane and sometimes a nucleoid, and ranges from 100 to 500 nm in size.
对13例拳师犬肉芽肿性结肠炎进行了电子显微镜研究，以确定巨噬细胞的内含物并寻找感染因子。巨噬细胞有三种类型。数量最多的巨噬细胞充满了由膜和平行膜对组成的残余体，许多呈圆形排列。第二种常见形式的巨噬细胞具有异质性细胞质，充满了含有各种大小和电子密度的许多小颗粒球体的吞噬体。最不常见的是含有吞噬泡的“年轻”巨噬细胞。13只犬中有4只的罕见巨噬细胞含有细菌。5只犬的巨噬细胞含有丰富的直径为100 - 500 nm的类球形、球杆菌形或分叶状颗粒结构，类似于衣原体。从吞噬颗粒到吞噬体再到残余体的转变很明显。拳师犬肉芽肿性结肠炎可能由一种富含脂质、富含核糖体、类球形到球杆菌形的生物体引起，该生物体具有细胞膜，有时还有拟核，大小在100到500 nm之间。
