Craven Melanie, Mansfield Caroline S, Simpson Kenneth W
Department of Veterinary Clinical Sciences, Cornell University, Tower Road, Ithaca, NY 14853-6401, USA.
Vet Clin North Am Small Anim Pract. 2011 Mar;41(2):433-45. doi: 10.1016/j.cvsm.2011.01.003.
Granulomatous colitis (GC) is a rare, breed-specific inflammatory bowel disease of young Boxer dogs. GC has been refractory to treatment and associated with high mortality rates, but culture-independent molecular analysis has transformed therapy and prognosis by uncovering a correlation between GC and Escherichia coli invasion within colonic mucosal macrophages. GC-associated invasive E coli are similar to a newly identified E coli pathotype, "adherent and invasive E coli," that are increasingly associated with Crohn's disease in humans. Successful treatment of GC requires antimicrobials that are effective against E coli and penetrate intracellularly. Enrofloxacin is widely regarded as the antibiotic of choice.
肉芽肿性结肠炎（GC）是一种罕见的、特定品种的年轻拳师犬炎性肠病。GC一直难以治疗且死亡率高，但非培养分子分析通过揭示GC与结肠黏膜巨噬细胞内大肠杆菌侵袭之间的相关性，改变了治疗方法和预后。与GC相关的侵袭性大肠杆菌类似于一种新发现的大肠杆菌致病型，即“黏附侵袭性大肠杆菌”，这种致病型与人类克罗恩病的关联日益增加。成功治疗GC需要使用对大肠杆菌有效的且能穿透细胞内的抗菌药物。恩诺沙星被广泛认为是首选抗生素。
