Zimmermann B, Adhami H
Z Mikrosk Anat Forsch. 1975;89(4):632-9.
The influence of cytosine-arabinoside (ara-C) on the nuclear size of monolayer cells from mouse brains were studied by quantitative analysis with the Quantimet (area measurement) and linear analysis with the Digiscan. Ara C (0,1; 1,0; 10,0 mug/ml) causes a significant nuclear enlargement, depending on the dose of 16%, 30% and 35% respectively and at the same time a decrease in cell density and an inhibition of mitotic activity. The size-distribution graph is altered by ara-C: the graph flattens and widens at the base. Moreover, in the case of 10,0 mug ara-C/ml a pronounced graph shoulder is visible in the small nuclear size region which can be interpreted as a slight accumulation of small nuclei. The nuclear enlargement is possibly due to an accumulation of shortchain polynucleotides.
通过使用图像分析系统（面积测量）进行定量分析以及使用数字扫描进行线性分析，研究了阿糖胞苷（ara-C）对小鼠大脑单层细胞细胞核大小的影响。阿糖胞苷（0.1、1.0、10.0微克/毫升）会导致细胞核显著增大，分别取决于剂量，增大比例为16%、30%和35%，同时细胞密度降低且有丝分裂活性受到抑制。阿糖胞苷改变了大小分布图：图形在底部变平且变宽。此外，在10.0微克阿糖胞苷/毫升的情况下，在小核大小区域可见明显的图形肩部，这可解释为小核的轻微积累。细胞核增大可能是由于短链多核苷酸的积累。
