Schultheiss Patricia C, Bedwell Cathy L, Hamar Dwayne W, Fettman Martin J
Colorado Diagnostic Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
J Vet Diagn Invest. 2002 Sep;14(5):396-402. doi: 10.1177/104063870201400506.
Concentrations of iron, copper, and zinc were measured in livers of 95 dogs that were suspected of having liver disease. Iron concentrations ranged from 177 to 7,680 ppm (dry weight basis); 54 dogs had iron concentrations greater than the normal concentration of 1,200 ppm. Iron stores were present in Kupffer cells and macrophages but not hepatocytes. The dogs did not have lesions of hemochromatosis. Dogs with high liver iron tended to have high liver copper and inflammatory lesions. High liver copper concentrations usually were associated with hepatocellular necrosis and fibrosis. High liver zinc was found in only 5 animals and was accompanied by histologic inflammatory lesions in one. In humans, increased iron concentration in the liver exacerbates liver damage caused by a variety of insults, and the same may be true for dogs.
对95只疑似患有肝脏疾病的犬的肝脏进行了铁、铜和锌浓度的测定。铁浓度范围为177至7680 ppm（干重基础）；54只犬的铁浓度高于正常浓度1200 ppm。铁储存存在于库普弗细胞和巨噬细胞中，而非肝细胞中。这些犬没有血色素沉着症的病变。肝脏铁含量高的犬往往肝脏铜含量高且有炎性病变。高肝脏铜浓度通常与肝细胞坏死和纤维化有关。仅在5只动物中发现肝脏锌含量高，其中1只伴有组织学炎性病变。在人类中，肝脏中铁浓度的增加会加剧由各种损伤引起的肝损伤，犬可能也是如此。
