Erba Daniela, Ciappellano Salvatore, Testolin Giulio
Department of Food Science and Microbiology, University of Milan, Italy.
Nutrition. 2002 Sep;18(9):743-6. doi: 10.1016/s0899-9007(02)00829-8.
We investigated the influence of different ratios between casein phosphopeptides and calcium (CPP/Ca) in intestinal lumen on passive Ca transport across the distal small intestine of rats in vitro.
We measured the amounts of passive Ca absorbed across the everted distal small intestine of rats with the use of radioactive 45Ca as tracer. Four CPP/Ca ratios (5, 10, 15, and 20 w/w) and three mineral concentrations (4, 8, and 12 mmol/L) were tested on groups of six rats.
We found a significant effect of the CPP/Ca ratio on mineral absorption (P < 0.001). The amounts of Ca absorbed increased from a ratio of 5 to a ratio of 15 and decreased with a ratio of 20, with a similar trend for every concentration tested. The more evident effect was found with the concentration of 12 mmol/L of Ca (P < 0.001 to 0.05).
The positive effect of CPPs on passive Ca absorption seems to depend on the relative amounts of both species in intestinal lumen. In this study, the ratio 15 was identified as the most efficient at increasing mineral transport. This evidence might be considered before suggesting CPP as a Ca dietary integrator, although more studies in vitro and in vivo are needed.
我们研究了肠腔内酪蛋白磷酸肽与钙（CPP/Ca）的不同比例对大鼠远端小肠被动钙转运的影响。
我们使用放射性45Ca作为示踪剂，测量了大鼠外翻远端小肠被动吸收的钙量。对每组六只大鼠测试了四种CPP/Ca比例（5、10、15和20 w/w）和三种矿物质浓度（4、8和12 mmol/L）。
我们发现CPP/Ca比例对矿物质吸收有显著影响（P < 0.001）。钙吸收量从比例5增加到比例15，并随着比例20而减少，对于每个测试浓度都有类似趋势。在钙浓度为12 mmol/L时发现了更明显的影响（P < 0.001至0.05）。
CPPs对被动钙吸收的积极作用似乎取决于肠腔内两种物质的相对量。在本研究中，比例15被确定为增加矿物质转运最有效的比例。在将CPP作为钙膳食补充剂推荐之前，可能需要考虑这一证据，尽管还需要更多的体外和体内研究。
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