McNees Adrienne L, Gooding Linda R
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Virus Res. 2002 Sep;88(1-2):87-101. doi: 10.1016/s0168-1702(02)00122-3.
Adenoviruses (Ads) are endemic in the human population and the well-studied group C Ads typically cause an acute infection in the respiratory epithelium. A growing body of evidence suggests that these viruses also establish a persistent infection. The Ad genome encodes several proteins that counteract the host anti-viral mechanisms, which function to limit viral infections. This review describes the adenovirus immuno-regulatory proteins and how they function to block apoptosis of infected cells. In addition to facilitating the successful completion of the viral replication cycle and spread of progeny virus, these functions may help maintain the virus in a persistent state.
腺病毒在人群中呈地方性流行，经过充分研究的C组腺病毒通常会在呼吸道上皮细胞中引发急性感染。越来越多的证据表明，这些病毒也会建立持续性感染。腺病毒基因组编码多种可对抗宿主抗病毒机制的蛋白质，这些机制的作用是限制病毒感染。本综述描述了腺病毒免疫调节蛋白及其阻断受感染细胞凋亡的作用机制。除了促进病毒复制周期的顺利完成和子代病毒的传播外，这些功能可能有助于病毒维持在持续感染状态。
