Shiriaeva V L
Antibiotiki. 1975 Aug;20(8):729-32.
Staphylococcus aureus, a laboratory strain 209-P and strain I isolated freshly from infected wounds, as well as lincomycin hydrochloride, ampicillin, oxacillin and methicillin manufactured in the USSR and cephaloridin manufactured by "PLIVA" in Yugoslavia were used. Various activity levels of desoxyribonuclease and lecitinase of the staphylococci depending on sensitivity or resistance of the test-microbe to the antibiotics were shown. The activity of the above microbial enzymes characterizing the pathogenic properties decreased with development of the antibiotic resistance, sometimes to complete inactivation of the enzymes synthesized by the staphylococci. In spite of closeness of their modes of action the semisynthetic penicillins had a differentiating effect on the above enzymes.
使用了金黄色葡萄球菌、实验室菌株209 - P和刚从感染伤口分离出的菌株I，以及苏联生产的盐酸林可霉素、氨苄青霉素、苯唑西林和甲氧西林，还有南斯拉夫“普利瓦”公司生产的头孢菌素。结果显示，根据测试微生物对这些抗生素的敏感或耐药情况，葡萄球菌的脱氧核糖核酸酶和卵磷脂酶具有不同的活性水平。上述表征致病特性的微生物酶的活性随着抗生素耐药性的产生而降低，有时会导致葡萄球菌合成的酶完全失活。尽管半合成青霉素的作用方式相近，但它们对上述酶有不同的影响。
