Pupkin M J, Schomberg D W, Nagey D A, Crenshaw C
Am J Obstet Gynecol. 1975 Jan 15;121(2):227-32. doi: 10.1016/0002-9378(75)90645-6.
The fetoplacental unit of the ewe is capable of increasing the biosynthesis of estrogens following the exogenous administration of DHEA to the fetus. The maximum concentrations of estrogens appeared approximately 30 minutes after the administration of DHEA. Uterine blood flow in the pregnant ewe increased approximately 90 minutes after the maximum concentrations of estrogens were noted. The administration of DHEA to the nonpregnant, ovariectomized ewe did not elicit estrogen biosynthesis or changes in uterine blood flow. Isotope experiments in the pregnant ewe demonstrated the incorporation of DHEA into urinary estradiol.
给母羊胎儿外源给予脱氢表雄酮（DHEA）后，其胎儿 - 胎盘单位能够增加雌激素的生物合成。给予DHEA后约30分钟出现雌激素的最高浓度。在观察到雌激素最高浓度后约90分钟，怀孕母羊的子宫血流量增加。给未怀孕、切除卵巢的母羊给予DHEA不会引发雌激素生物合成或子宫血流量的变化。对怀孕母羊进行的同位素实验表明DHEA可掺入尿雌二醇中。
