Rosenfeld C R, Worley R J, Gant N
Obstet Gynecol. 1977 Sep;50(3):304-7.
The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg +/- 0.3. Maximum blood flows occurred 111 min +/- 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.6 pg/ml to 115 pg/ml (P less than 0.001). Estriol was not detected.
在7只妊娠52至128天的怀孕母羊中，研究了全身输注脱氢表雄酮对绵羊妊娠期间子宫血流量和血浆雌激素浓度的影响。全身输注4.67毫克±0.3毫克脱氢表雄酮后，子宫血流量增加了17.8%。注射脱氢表雄酮后111分钟±5.8分钟出现最大血流量。妊娠100天后，血流量增加（毫升/分钟）最大。血浆雌酮浓度从67.9皮克/毫升增加到201皮克/毫升，而雌二醇从42.6皮克/毫升增加到115皮克/毫升（P<0.001）。未检测到雌三醇。
