肾移植后红细胞膜哇巴因敏感的三磷酸腺苷酶的变化

Changes in erythrocyte membrane ouabain-sensitive adenosine triphosphatase after renal transplantation.

Cole C H, Maletz R

Clin Sci Mol Med. 1975 Mar;48(3):239-42. doi: 10.1042/cs0480239.

Abstract

Intracellular electrolytes, and erythrocyte membrane adenosine triphosphatase (ATPase) activity, was studied in twenty patients after renal transplantation. 2. The mean ouabain-sensitive ATPase activity in the erythrocyte membranes of the transplant patients was 122 nmol of inorganic phosphorus (Pi) h-1 mg of tissue-1 (SEM 14), compared with 62 nmol of Pi h-1 mg of tissue-1 (SEM 8) in a group of paired, healthy controls. 3. The increase in ouabain-sensitive ATPase was most marked in the 4 months after transplantation. However, a significant increase in ouabain-sensitive ATPase persisted for more than 8 months after transplantation. 4. This increase in ouabain-sensitive ATPase was associated with a decrease in intracellular sodium in the erythrocytes of the transplant patients.

摘要

对20例肾移植患者的细胞内电解质及红细胞膜腺苷三磷酸酶（ATP酶）活性进行了研究。2. 移植患者红细胞膜中哇巴因敏感的ATP酶活性平均为122 nmol无机磷（Pi）·h⁻¹·mg组织⁻¹（标准误14），而一组配对的健康对照者为62 nmol Pi·h⁻¹·mg组织⁻¹（标准误8）。3. 移植后4个月内，哇巴因敏感的ATP酶增加最为显著。然而，移植后8个月以上，哇巴因敏感的ATP酶仍持续显著增加。4. 移植患者红细胞内钠含量降低与哇巴因敏感的ATP酶增加有关。