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肾移植后红细胞膜哇巴因敏感的三磷酸腺苷酶的变化

Changes in erythrocyte membrane ouabain-sensitive adenosine triphosphatase after renal transplantation.

作者信息

Cole C H, Maletz R

出版信息

Clin Sci Mol Med. 1975 Mar;48(3):239-42. doi: 10.1042/cs0480239.

DOI:10.1042/cs0480239
PMID:123185
Abstract
  1. Intracellular electrolytes, and erythrocyte membrane adenosine triphosphatase (ATPase) activity, was studied in twenty patients after renal transplantation. 2. The mean ouabain-sensitive ATPase activity in the erythrocyte membranes of the transplant patients was 122 nmol of inorganic phosphorus (Pi) h-1 mg of tissue-1 (SEM 14), compared with 62 nmol of Pi h-1 mg of tissue-1 (SEM 8) in a group of paired, healthy controls. 3. The increase in ouabain-sensitive ATPase was most marked in the 4 months after transplantation. However, a significant increase in ouabain-sensitive ATPase persisted for more than 8 months after transplantation. 4. This increase in ouabain-sensitive ATPase was associated with a decrease in intracellular sodium in the erythrocytes of the transplant patients.
摘要
  1. 对20例肾移植患者的细胞内电解质及红细胞膜腺苷三磷酸酶(ATP酶)活性进行了研究。2. 移植患者红细胞膜中哇巴因敏感的ATP酶活性平均为122 nmol无机磷(Pi)·h⁻¹·mg组织⁻¹(标准误14),而一组配对的健康对照者为62 nmol Pi·h⁻¹·mg组织⁻¹(标准误8)。3. 移植后4个月内,哇巴因敏感的ATP酶增加最为显著。然而,移植后8个月以上,哇巴因敏感的ATP酶仍持续显著增加。4. 移植患者红细胞内钠含量降低与哇巴因敏感的ATP酶增加有关。

相似文献

1
Changes in erythrocyte membrane ouabain-sensitive adenosine triphosphatase after renal transplantation.肾移植后红细胞膜哇巴因敏感的三磷酸腺苷酶的变化
Clin Sci Mol Med. 1975 Mar;48(3):239-42. doi: 10.1042/cs0480239.
2
Alteration in intracellular sodium concentration and ouabain-sensitive ATPase in erythrocytes from hyperthyroid patients.甲状腺功能亢进患者红细胞内钠浓度及哇巴因敏感性ATP酶的改变。
J Clin Endocrinol Metab. 1976 Jun;42(6):1056-63. doi: 10.1210/jcem-42-6-1056.
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Variability in ouabain-induced inhibition of human erythrocyte membrane (Na+ K+)-ATPase.
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Effect of ozone on erythrocyte membrane adenosine triphosphatase.臭氧对红细胞膜三磷酸腺苷酶的影响。
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引用本文的文献

1
Glucocorticoid-induced alterations in the sodium potassium pump of the human erythrocyte.糖皮质激素诱导的人红细胞钠钾泵变化
J Clin Invest. 1981 Aug;68(2):422-30. doi: 10.1172/jci110271.
2
Mechanism of alteration of sodium potassium pump of erythrocytes from patients with chronic renal failure.慢性肾功能衰竭患者红细胞钠钾泵改变的机制
J Clin Invest. 1984 Nov;74(5):1811-20. doi: 10.1172/JCI111600.
3
Erythrocyte Na(+)-K+ ATPase activity in the genesis of reducing renal mass in hypertensive rats.红细胞钠钾ATP酶活性在高血压大鼠肾质量减轻发生过程中的作用
Korean J Intern Med. 1986 Jul;1(2):185-93. doi: 10.3904/kjim.1986.1.2.185.