Jonas E A, Aloia J F, Lane F J
Chest. 1975 Feb;67(2):190-4. doi: 10.1378/chest.67.2.190.
A group of ten acromegalic patients, who had no history of heart failure, was studied to determine whether subtle carciac impairment may also be common. None had clinical evidence of coronary artery disease or severe hypertension. Systolic time intervals were recorded in each patient and compared with normal values predicted for sex and heart rate by our own controls and published data. The results indicate that measurable abnormalities in left ventricular performance are common in this sampling. Known duration and activity of disease (growth hormone levels at time of study) did not correlate with the time intervals. The results are consistent with cardiomyopathic effect of excessive growth hormone.
一组十名无心力衰竭病史的肢端肥大症患者接受了研究，以确定轻微的心脏损害是否也很常见。他们均无冠状动脉疾病或严重高血压的临床证据。记录了每位患者的收缩期时间间期，并与根据我们自己的对照组以及已发表数据按性别和心率预测的正常值进行比较。结果表明，在该样本中左心室功能存在可测量的异常很常见。已知的疾病持续时间和活动情况（研究时的生长激素水平）与时间间期并无关联。这些结果与过量生长激素的心肌病效应相符。
