Mather H M, Boyd M J, Jenkins J S
Br Heart J. 1979 Jun;41(6):697-701. doi: 10.1136/hrt.41.6.697.
Cardiac size and function was studied in 23 acromegalic patients using echocardiography and systolic time interval measurements. Thirteen patients (56%) had increased left ventricular mass, and in the 20 treated patients this correlated well with the mean of the recent basal growth hormone levels. It is suggested that myocardial hypertrophy may regress in proportion to the degree of control of growth hormone levels. The ejection fraction was normal in all patients except one, and increased left ventricular mass was not associated with detectable impairment of left ventricular performance. Thus, most acromegalic hearts function normally even when their mass is considerably increased, though the long-term effects of this are unknown, Echocardiography will be valuable in the serial monitoring of the cardiac effects of acromegaly.
采用超声心动图和收缩期时间间期测量方法，对23例肢端肥大症患者的心脏大小和功能进行了研究。13例患者（56%）左心室质量增加，在20例接受治疗的患者中，这与近期基础生长激素水平的平均值密切相关。提示心肌肥厚可能会随着生长激素水平控制程度的降低而消退。除1例患者外，所有患者的射血分数均正常，左心室质量增加与左心室功能可检测到的损害无关。因此，即使大多数肢端肥大症患者的心脏质量显著增加，其心脏功能仍正常，尽管其长期影响尚不清楚，但超声心动图在肢端肥大症心脏效应的系列监测中将具有重要价值。
