Schnaufer L, Koop C E
J Pediatr Surg. 1975 Feb;10(1):73-5. doi: 10.1016/s0022-3468(75)80012-1.
Of our 174 neuroblastoma patients, 11 were classified as Stage IV-S. The primary tumor is usually small and there is widespread disease in the liver, skin, bone marrow, or any combination of these. The prognosis is favorable and radiation and chemotherapy should be avoided if possible. In some of these children the rapidly enlarging liver may cause respiratory distress and vena caval compression. The creation of a ventral hernia by means of a Silastic patch is a useful, temporary procedure during the life-threatening period of rapid growth and increased intra-abdominal pressure. Closure is simple once the liver has returned to normal.
在我们的174例神经母细胞瘤患者中,11例被归类为IV-S期。原发肿瘤通常较小,但肝脏、皮肤、骨髓会出现广泛病变,或出现上述部位的任意组合病变。预后良好,应尽可能避免放疗和化疗。在一些此类患儿中,快速增大的肝脏可能会导致呼吸窘迫和腔静脉受压。在快速生长和腹内压升高的危及生命阶段,通过硅胶补片制造腹疝是一种有用的临时手术。一旦肝脏恢复正常,闭合手术很简单。