Karlsson E, Aberg G, Collste P, Molin L, Norlander B, Sjöqvist F
Eur J Clin Pharmacol. 1975;8(1):79-81. doi: 10.1007/BF00616419.
The metabolism of procaine amide was studied in 41 cardiac patients who had achieved steady state plasma concentrations of the drug. Acetylated procaine amide accounted for 31 +/- 12% (range 16-63%) of the overall urinary recovery of the drug and is therefore a main metabolite in man. Plasma levels of the metabolite were usually lower but sometimes exceeded those of the parent compound with variations between 1 and 15 mug/ml. The metabolite had a weaker effect than procaine amide on the maximal electrical driving velocity of isolated atrial strips from guinea pig.
对41例已达到药物稳态血药浓度的心脏病患者进行了普鲁卡因胺代谢的研究。乙酰化普鲁卡因胺占该药物尿中总回收率的31±12%（范围为16 - 63%），因此是人体中的主要代谢产物。该代谢产物的血浆水平通常较低，但有时会超过母体化合物，其变化范围在1至15微克/毫升之间。该代谢产物对豚鼠离体心房条最大电驱动速度的作用比普鲁卡因胺弱。
