大鼠肝脏N-乙酰转移酶对普鲁卡因胺和异烟肼的乙酰化作用。
Acetylation of procainamide and isoniazid by a rat liver-N-acetyl-transferase.
作者信息
Kattner E, Dubbels R, Schloot W
出版信息
Eur J Drug Metab Pharmacokinet. 1981;6(2):81-4. doi: 10.1007/BF03189472.
The genetic variation of the enzyme isoniazid-N-acetyltransferase has been studied in man and other species. Homogenates of liver samples of adult LEW rats also acetylate procainamide. The kinetic properties of isoniazid and procainamide acetylation are similar and are consistent with a ping-pong Bi-Bi mechanism. The experimental data support the hypothesis that one acetyltransferase catalyses both procainamide and isoniazid. Furthermore, a simple spectrophotometric assay to determine procainamide acetylation is presented.
人们已经对异烟肼 - N - 乙酰转移酶在人类和其他物种中的基因变异进行了研究。成年LEW大鼠肝脏样本的匀浆也能使普鲁卡因酰胺乙酰化。异烟肼和普鲁卡因酰胺乙酰化的动力学特性相似，符合乒乓双底物双产物机制。实验数据支持一种乙酰转移酶催化普鲁卡因酰胺和异烟肼的假说。此外，还介绍了一种用于测定普鲁卡因酰胺乙酰化的简单分光光度法。
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