Overo K F, Gram L F, Hansen V
Eur J Clin Pharmacol. 1975 Jun 13;8(5):343-7. doi: 10.1007/BF00562660.
Plasma concentrations of nortriptyline have been assayed in four subjects after intravenous infusion of 57 mg nortriptyline hydrochloride. The data were evaluated according to a two compartment open model. The calculated best-fitting curves were in good agreement with the experimental data, better than could be expected from a simpler model. This justifies the assumption that the kinetics of nortriptyline in man may be described by this model with an appropriate input function. The data permitted estimation of all the parameters of the model. The meaning of the parameters is discussed, particularly in relation to individual variation.
在四名受试者静脉输注57毫克盐酸去甲替林后，测定了他们血浆中去甲替林的浓度。数据根据二室开放模型进行评估。计算出的最佳拟合曲线与实验数据吻合良好，比简单模型预期的要好。这证明了这样一种假设是合理的，即去甲替林在人体内的动力学可以用该模型结合适当的输入函数来描述。这些数据允许对模型的所有参数进行估计。讨论了这些参数的意义，特别是与个体差异有关的方面。
