Neuvonen P J, Penttilä O, Lehtovaara R, Aho K
Eur J Clin Pharmacol. 1975 Dec 19;9(2-3):147-54. doi: 10.1007/BF00614011.
Elimination of the bacteriostatics tetracycline, doxycycline, methacycline, oxytetracycline, demethylchlortetracycline and chlortetracycline was studied in healthy control persons and in patients on long-term antiepileptic therapy. The half-life of doxycycline was significantly shorter in patients than in the controls. The half-lives of other tetracycline derivatives and their excretion in urine were not significantly different between the two groups. Accordingly, in order to maintain an adequate serum level of doxycycline it should be given twice daily to patients on long-term therapy with barbiturates, diphenylhydantoin or carbamazepine. The classical tetracycline derivatives studied may be administered according to conventional principles.
在健康对照者和长期接受抗癫痫治疗的患者中研究了抑菌剂四环素、多西环素、甲烯土霉素、土霉素、去甲金霉素和金霉素的消除情况。多西环素在患者中的半衰期明显短于对照者。两组之间其他四环素衍生物的半衰期及其尿排泄无显著差异。因此，为维持多西环素的足够血清水平，对于长期接受巴比妥类、苯妥英或卡马西平治疗的患者，应每日给药两次。所研究的经典四环素衍生物可按照常规原则给药。
