氚标记的前列腺素A1在大鼠体内的胎盘转运

Placental transfer of tritium-labelled prostaglandin A1 in the rat.

作者信息

Persaud T V, Jackson C W

出版信息

Exp Pathol (Jena). 1975;10(5-6):353-8. doi: 10.1016/s0014-4908(75)80044-5.

Abstract

Pregnant Long Evans rats were treated with 25 muCi 3 H-prostaglandin A1 on either gestational day 15, 18 or 21. The highest concentrations of radioactivity were found in maternal kidneys, lungs and liver. The levels of radioactivity in the gut and also in amniotic fluid markedly increased with time after isotope administration. Significant levels of radioactivity were present in fetal tissues and in the placenta.

摘要

对怀孕的Long Evans大鼠在妊娠第15、18或21天用25微居里的3H-前列腺素A1进行处理。在母体的肾脏、肺和肝脏中发现了最高浓度的放射性。给药后，肠道和羊水中的放射性水平随时间显著增加。胎儿组织和胎盘中存在显著水平的放射性。