前列腺素F1α在妊娠大鼠体内的分布

Distribution of prostaglandin F1 alpha in the pregnant rat.

作者信息

Persaud T V

出版信息

Prostaglandins Med. 1980 Feb;4(2):95-100. doi: 10.1016/0161-4630(80)90040-3.

Abstract

The placental transfer and tissue distribution of tritium-labelled prostaglandin F1 alpha was investigated in rats on day 14 of gestation. Low levels of radioactivity were detected in the embryos and placentas 5, 10, 60, and 120 minutes after administration of the prostaglandin, but the concentration in amniotic fluid was extremely high at all time intervals. Maternal serum, kidney, liver and lung revealed a greater uptake of the isotope compared to the uterus, ovary, spleen and brain. It is conceivable that the high levels of prostaglandin accumulated in the amniotic fluid may act directly on the conceptus.

摘要

在妊娠第14天的大鼠中，研究了氚标记的前列腺素F1α的胎盘转运和组织分布。给予前列腺素后5、10、60和120分钟，在胚胎和胎盘中检测到低水平的放射性，但在所有时间间隔羊水中的浓度都极高。与子宫、卵巢、脾脏和大脑相比，母体血清、肾脏、肝脏和肺对该同位素的摄取更多。可以想象，羊水中积累的高水平前列腺素可能直接作用于胎儿。