Gabriel W
Prakt Anaesth. 1975 Feb;10(1):1-9.
During laryngeal surgery with succinyldicholine relaxation it was noticed that the effects of the drug faded most quickly in the laryngeal muscles. To substantiate this observation an electromyographic study was made in 36 patients. 116 comparable action potentials were simultaneously recorded from the interarytenoid and flexor carpiulnaris muscles on a 4-track magnetic tape. An analysis of the recordings showed that action potentials in the larynx always re-appeared before those in the arm muscles. These results are different from those obtained by Spillmann who recorded action potentials in the tongue and arm. The time-lag between resumption of electrical activity in the larynx and the arm averaged 58 seconds. Possible causes of this difference are discussed. Succinyldicholine becomes effective 30 seconds after intravenous injection and its effects last 60-90 seconds. Recording the action potentials in the larynx during anaesthesia allows the accurate timing of further doses of muscle relaxants.
在使用琥珀酰胆碱进行肌肉松弛的喉部手术过程中，人们注意到该药物在喉部肌肉中的作用消退得最快。为证实这一观察结果，对36例患者进行了肌电图研究。在四轨磁带上同时记录了来自杓间肌和尺侧腕屈肌的116个可比动作电位。对记录的分析表明，喉部的动作电位总是比手臂肌肉中的动作电位先重新出现。这些结果与Spillmann在舌头和手臂记录动作电位所获得的结果不同。喉部和手臂恢复电活动之间的时间间隔平均为58秒。讨论了造成这种差异的可能原因。琥珀酰胆碱静脉注射后30秒开始起效，其作用持续60 - 90秒。在麻醉期间记录喉部的动作电位有助于准确确定进一步使用肌肉松弛剂的时间。
