血浆和尿液中的泼尼松龙水平：对人体两种制剂的研究。
Prednisolone levels in the plasma and urine: a study of two preparations in man.
作者信息
English J, Chakraborty J, Marks V, Trigger D J, Thomson A G
出版信息
Br J Clin Pharmacol. 1975 Aug;2(4):327-32. doi: 10.1111/j.1365-2125.1975.tb02779.x.
Abstract
- A competitive protein binding method was used to measure prednisolone and cortisol in blood and urine of volunteers given prednisolone by mouth (15 mg) in the standard tablet form and a fortnight later a regulated release formulation of prednisolone metasulphobenzoate containing an equivalent amount of prednisolone. 3. Plasma prednisolone levels rose rapidly after the standard tablet and more slowly after the regulated release form. The normal activity of the hypothalamic-pituitary-adrenal axis as measured by the 09.00 h plasma cortisol concentration was present 24 h after ingestion of the regulated release preparation. In contrast, the 09.00 h plasma cortisol level was reduced in subjects 24 h after receiving prednisolone in the standard tablet form.
摘要
- 采用竞争性蛋白结合法，对口服标准片剂形式的泼尼松龙（15毫克）的志愿者的血液和尿液中的泼尼松龙和皮质醇进行测定，两周后，又对服用含等量泼尼松龙的甲磺苯甲酸泼尼松龙控释制剂的志愿者进行了测定。3. 服用标准片剂后血浆泼尼松龙水平迅速上升，而服用控释制剂后上升较慢。服用控释制剂24小时后，通过上午9点血浆皮质醇浓度测定的下丘脑 - 垂体 - 肾上腺轴的正常活性依然存在。相比之下，服用标准片剂形式的泼尼松龙24小时后，受试者上午9点的血浆皮质醇水平降低。
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本文引用的文献
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STUDIES ON AN INTERMITTENT CORTICOSTEROID DOSAGE REGIMEN.间歇性皮质类固醇给药方案的研究
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Conversion of cortisone to cortisol and prednisone to prednisolone.可的松向皮质醇的转化以及泼尼松向泼尼松龙的转化。
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Suppression of 17-hydroxycorticosteroids in plasma and urine by single and divided doses of triamcinolone.曲安奈德单次及分次给药对血浆和尿液中17-羟皮质类固醇的抑制作用。
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Radioimmunoassay for prednisolone.
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