用放射免疫分析法测定人单剂量苯妥英的药代动力学。
Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.
作者信息
Robinson J D, Morris B A, Aherne G W, Marks V
出版信息
Br J Clin Pharmacol. 1975 Aug;2(4):345-9. doi: 10.1111/j.1365-2125.1975.tb02782.x.
Abstract
- Serum concentrations of phenytoin were studied by radioimmunoassay in five normal volunteers following a single oral dose of phenytoin sodium (100 mg). 2. Two distinct peaks were found at 2.5-3.5 and 10-12 h after ingestion. Maximum serum concentrations ranged from 1.56 mug/ml. The mean plasma half-life of the drug under these conditions was 9.81 +/- 0.66 (s.e. mean) hours.
摘要
- 采用放射免疫分析法研究了5名正常志愿者单次口服苯妥英钠（100毫克）后的血清苯妥英浓度。2. 服药后2.5 - 3.5小时和10 - 12小时出现两个明显的峰值。血清最高浓度范围为1.56微克/毫升。在这些条件下，该药物的平均血浆半衰期为9.81±0.66（标准误均值）小时。
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