静脉输注沙丁胺醇治疗哮喘。
Intravenous infusion of salbutamol in the treatment of asthma.
作者信息
Spiro S G, Johnson A J
出版信息
Br J Clin Pharmacol. 1975 Dec;2(6):503-8. doi: 10.1111/j.1365-2125.1975.tb00567.x.
Abstract
The effects of i.v. infusion of increasing rates of salbutamol for up to 4 h were documented in ten convalescent asthmatic patients. 2 The major bronchodilator effect was seen at 4.16 mug/minute. A small further improvement occurred at infusion rates up to 25.0 mug/min but was not significantly better than that seen at the lower infusion rate. 3 Cardiovascular effects were minimal after 60 min at the lower rate and even at 25.0 mug/min mean heart rate rose by only 17.1 beats/minute. All patients tolerated the 4 h infusion well. 4 It is concluded that i.v. infusion of salbutamol may be a useful addition to the treatment of the patient with a severe attack of asthma.
摘要
对10例恢复期哮喘患者静脉输注不同速率沙丁胺醇长达4小时的效果进行了记录。2主要支气管扩张作用出现在4.16微克/分钟时。输注速率高达25.0微克/分钟时出现了进一步的小幅改善，但并不比低输注速率时显著更好。3较低速率输注60分钟后心血管效应极小，即使在25.0微克/分钟时平均心率仅上升17.1次/分钟。所有患者对4小时输注耐受性良好。4得出结论，静脉输注沙丁胺醇可能是重度哮喘发作患者治疗中的一种有用补充。
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