Richter P H
Eur J Immunol. 1975 May;5(5):350-4. doi: 10.1002/eji.1830050511.
The fact that every antibody also has antigenic properties leads to the existence of a functional network of interacting antibodies and lymphocytes in the immune system. With a minimum set of assumptions about the nature of these interactions some of the principal features of the immune response such as normal primary and secondary response, low and high zone tolerance induction, and memory can be reproduced. The low zone tolerance phenomenon plays a central role in our theory, as it is the simplest nontrivial mode of response to an antigenic stimulus. It may be understood as the defeat of the stimulated lymphocyte species against their internal adversaries. The normal response and high zone tolerance induction may be characterized as low zone tolerance on a second and third level of a hierarchy of lymphocyte populations. In particular, the weakness of the primary response is explained in terms of internal struggles which lead to a final suppression of the aggressors, thereby opening the way for an unhindered secondary response.
每种抗体都具有抗原特性这一事实，导致免疫系统中存在一个由相互作用的抗体和淋巴细胞组成的功能网络。基于对这些相互作用本质的最少假设，可以重现免疫反应的一些主要特征，如正常的初次和二次反应、低区和高区耐受性诱导以及记忆。低区耐受性现象在我们的理论中起着核心作用，因为它是对抗抗原刺激最简单的非平凡反应模式。它可以被理解为受刺激的淋巴细胞群体战胜其内部对手。正常反应和高区耐受性诱导可被描述为淋巴细胞群体层次结构第二和第三级的低区耐受性。特别是，初次反应的弱点可以用内部斗争来解释，这种斗争导致攻击者最终被抑制，从而为不受阻碍的二次反应开辟道路。
