Arroyo V, Rodés J
Postgrad Med J. 1975 Aug;51(598):558-62. doi: 10.1136/pgmj.51.598.558.
A rational approach to the diuretic therapy of ascites is proposed. Fifty-five patients were classified according to their ability to excrete sodium and free water. Patients with a high urinary sodium excretion can be treated by low sodium intake alone. In most patients with a low sodium excretion but high free water clearance, distal diuretics (spironolactone or triamterene) with a low sodium diet will relieve ascites. Patients with low values for sodium excretion and free water clearance also have poor glomerular filtration rate and only a few of these will respond to diuretic therapy.
本文提出了一种治疗腹水的利尿疗法的合理方法。55例患者根据其排泄钠和自由水的能力进行分类。尿钠排泄高的患者仅通过低钠摄入即可治疗。大多数尿钠排泄低但自由水清除率高的患者，使用远端利尿剂（螺内酯或氨苯蝶啶）并采用低钠饮食可缓解腹水。钠排泄和自由水清除率低的患者肾小球滤过率也低，其中只有少数患者会对利尿疗法有反应。
