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乙醇对犬去神经支配胃袋分泌及黏膜血流的影响。

Effects of ethanol on the secretion and mucosal blood flow of a denervated gastric pouch in the dog.

作者信息

De Saint Blanquat G, Lamboeuf Y, Derache R

出版信息

Eur J Pharmacol. 1975 Nov;34(1):219-22. doi: 10.1016/0014-2999(75)90242-3.

DOI:10.1016/0014-2999(75)90242-3
PMID:1234765
Abstract

Mucosal secretion and blood flow of a Heidenhain pouch were measured in dogs after orally administered ethanol at doses from 0.25 to 2 g/kg of body weight. Under these conditions, the volume, free and total acidity of the gastric juice as well as mucosal blood flow increased linearly with the dose up to 1 g/kg. In all cases volume secreted and acidity chanm the other parameters and could not be correlated with blood flow. The influence of gastrin and the modification of membrane permeability are discussed with regard to these data.

摘要

给体重为0.25至2 g/kg的犬口服乙醇后,测量其海登海因小胃的黏膜分泌和血流量。在这些条件下,胃液的体积、游离酸度和总酸度以及黏膜血流量随剂量增加至1 g/kg呈线性增加。在所有情况下,分泌的体积和酸度变化与其他参数无关,且与血流量无相关性。结合这些数据讨论了胃泌素的影响和膜通透性的改变。

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