阿司匹林类药物对犬胃黏膜血流及胃酸分泌的影响。
Effects of aspirin-like drugs on canine gastric mucosal blood flow and acid secretion.
作者信息
Bennett A, Curwain B P
出版信息
Br J Pharmacol. 1977 Aug;60(4):499-504. doi: 10.1111/j.1476-5381.1977.tb07527.x.
Abstract
- The effects of aspirin, paracetamol and benorylate were studied on gastric mucosal blood flow (MBF) and acid secretion in canine denervated gastric pouches. 2. Aspirin 20 mM in the unstimulated pouch had no effect; pentagastrin-stimulated acid output, but not MBF, was reduced. Aspirin buffered to pH 6 was ineffective. 3. Aspirin 3-50 mg/kg reaching the pentagastrin-stimulated pouch through the blood, increased acid secretion and MBF, but the MBF:secretion ratio was variably affected. 4. Paracetamol (10 or 20 mg/kg i.v., or 20 mM in the pouch) or benorylate (280 mg/kg orally) mainly had little effect. 5. Circular muscle strips from dog arteries were contracted by prostaglandins E2, F1alpha or F2alpha, and often slightly by indomethacine, but prostaglandin E1 produced variable effects. 6. These results do not favour the view that aspirin causes gastric bleeding in dogs by breakdown of blood vessels due to ischaemia following mucosal vasoconstriction.
摘要
- 研究了阿司匹林、对乙酰氨基酚和贝诺酯对犬去神经胃小囊胃黏膜血流量（MBF）和胃酸分泌的影响。2. 在未受刺激的胃小囊中，20 mM的阿司匹林无作用；五肽胃泌素刺激的胃酸分泌减少，但MBF未受影响。缓冲至pH 6的阿司匹林无效。3. 通过血液到达五肽胃泌素刺激的胃小囊的3 - 50 mg/kg阿司匹林，增加了胃酸分泌和MBF，但MBF与分泌的比率受到不同程度的影响。4. 对乙酰氨基酚（静脉注射10或20 mg/kg，或胃小囊中20 mM）或贝诺酯（口服280 mg/kg）主要无明显作用。5. 前列腺素E2、F1α或F2α可使犬动脉的环形肌条收缩，吲哚美辛常使其轻微收缩，但前列腺素E1产生的作用不一。6. 这些结果不支持阿司匹林通过黏膜血管收缩后缺血导致血管破裂而引起犬胃出血的观点。
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