Nikolaeva L F, Cherpachenko N M, Sokolova R I, Veselova S P, Goldikov P P
Kardiologiia. 1975 Oct;15(10):124-31.
On a model of experimental myocardial infarction produced through ligation of the anterior descending branch of the coronary artery it is shown that inosine is capable of raising the activity of a number of respiratory enzymes, chiefly in the extra-infarction sectors of the myocardium, as well as in the perinecrotic areas and in intact muscular elements within the necrotic zone. It also helps accelerate the formation of the post-infarction scar. Under the effect of inosine the integrity and functional activity of the mitochondria are improved, the noradrenaline concentration in the myocardium is normalized more rapidly, the processes of the myocardial hypertrophy develop successfully and the contractility of the heart muscle increases. Investigations were conducted on 108 rabbits and they included histological, histochemical, electron-microscopic, biochemical methods, as well as electrocardiography and determination of intracardiac hemodynamics.
在通过结扎冠状动脉前降支产生的实验性心肌梗死模型上，研究表明肌苷能够提高多种呼吸酶的活性，主要是在心肌梗死灶以外的区域，以及坏死周边区和坏死区内完整的肌细胞。它还有助于加速梗死灶后瘢痕的形成。在肌苷的作用下，线粒体的完整性和功能活性得到改善，心肌中去甲肾上腺素浓度更快恢复正常，心肌肥大过程顺利发展，心肌收缩力增强。对108只兔子进行了研究，研究方法包括组织学、组织化学、电子显微镜、生物化学方法，以及心电图检查和心内血流动力学测定。
