Kipshidze N N, Korotkov A A, Chapidze G E, Marsagishvili L A, Todua E I
Kardiologiia. 1978 Mar;18(3):18-28.
The effect of the nucleoside Inosie-F (inosin) on the intracardiac hemodynamics and the contraction and relaxation of a diseased myocardium was studied in the clinic and in experiments. An examination was made of 102 patients with macrofocal myocardial infarction (22 received inosin by intravenous drip in a single dose of 200 mg in the acute stage of infarction; 60 patients were given inosin pills in a daily dose of 800 mg in the restoration period for one month, and 20 patients were given placebo). Comparative appraisal of treatment in the period of rehabilitation showed prevailing improvement in the condition of individuals treated with inosin, positive ECG dynamics, increase of cardiac output and decrease of peripheral resistance. In experiments on 28 dogs with a model of acute myocardial ischemia a noticeable improvement in myocardial contraction and relaxation in the absence of negative ECG dynamics was recorded after intravenous infusion of inosin. Inosin achieves maximum effect by 60-90 mins after the beginning of infusion.
在临床和实验中研究了核苷肌苷-F（肌苷）对心内血流动力学以及病变心肌收缩和舒张的影响。对102例大面积心肌梗死患者进行了检查（22例在梗死急性期通过静脉滴注单剂量200mg肌苷；60例患者在恢复期每日服用800mg肌苷片，持续一个月，20例患者服用安慰剂）。康复期治疗的比较评估显示，接受肌苷治疗的个体状况普遍改善，心电图呈阳性动态变化，心输出量增加，外周阻力降低。在28只急性心肌缺血模型犬的实验中，静脉输注肌苷后，记录到心肌收缩和舒张有明显改善，且心电图无阴性动态变化。肌苷在输注开始后60 - 90分钟达到最大效果。
