Golikov A P, Karev V A, Polumiskov V Iu, Konorev L A, Berestov A A
Kardiologiia. 1988 Nov;28(11):46-50.
A study of 102 patients with primary macrofocal myocardial infarction, admitted to hospital within the first 6 hours after the onset of the disease, and experimental evidence obtained in 110 Wistar rats are reported. In a control group of myocardial infarction patients, collagen synthesis was depressed in the presence of the activation of free-radical lipid oxidation and circulatory hypoxia. Piracetam and inosine treatment was associated with the inhibition of free-radical lipid oxidation and a reduction of hypoxia, those being accompanied by increased collagenogenesis and accelerated postinfarction scar formation. Piracetam, as compared to inosine, had a more marked stimulating effect on the development of compensatory myocardial hypertrophy, thus contributing to rapid recovery of cardiac contractility and reducing manifestations of circulatory insufficiency.
报告了一项对102例原发性大灶性心肌梗死患者的研究，这些患者在疾病发作后的前6小时内入院，以及在110只Wistar大鼠身上获得的实验证据。在心肌梗死患者的对照组中，在自由基脂质氧化激活和循环性缺氧的情况下，胶原合成受到抑制。吡拉西坦和肌苷治疗与自由基脂质氧化的抑制和缺氧的减轻相关，同时伴随着胶原生成增加和梗死灶后瘢痕形成加速。与肌苷相比，吡拉西坦对代偿性心肌肥大的发展具有更显著的刺激作用，从而有助于心脏收缩力的快速恢复并减少循环功能不全的表现。
