Almazov V A, Ermilov L P, Temirov A A, Shabrov A V
Kardiologiia. 1975 Oct;15(10):131-6.
Cardio- and hemodynamics was investigated in 69 patients with chronic coronary insufficiency without manifestations of cardiac decompensation and with symptoms of congestive incompetence of the heart by using radiocardiography and analyzing systolic phases of the left ventricle. Furthermore, fractional composition of myocardial proteins and the ATP-ase myosin activity were studied in 31 persons, who during their life-time suffered from ischemic heart disease. In patients presenting no symptoms of cardiac insufficiency significant changes in cardio- and hemodynamics along with a reduced content of the actomyosin complex proteins and their disturbed ATP-ase activity were uncovered. These changes proved more intensive in the face of manifestations indicating cardiac decompensation. Thus, a complex investigation of cardio- and hemodynamics enabled it to disclose initial disorders in the contractile activity of the myocardium in patients with chronic coronary insufficiency, when such disturbances are associated both with deranged utilization and with defective accumulation of energy in the myocardium.
通过放射性心动图并分析左心室收缩期，对69例无心脏代偿失调表现但有心脏充血性功能不全症状的慢性冠状动脉供血不足患者进行了心脏和血液动力学研究。此外，对31例生前患有缺血性心脏病的患者进行了心肌蛋白的分数组成和肌球蛋白ATP酶活性研究。在无心脏功能不全症状的患者中，发现心脏和血液动力学有显著变化，同时肌动球蛋白复合蛋白含量降低及其ATP酶活性紊乱。在出现心脏代偿失调表现时，这些变化更为明显。因此，对心脏和血液动力学的综合研究能够揭示慢性冠状动脉供血不足患者心肌收缩活动的初始紊乱，此时这种紊乱与心肌能量利用紊乱和能量积累缺陷均有关。
