Ahmad M, Jan M, Ali W, Bashir C, Iqbal Q
JK Pract. 2000 Apr-Jun;7(2):125-6.
Neonatal cholestasis is prolonged elevation of conjugated serum bilirubin (more than 20% of total bilirubin) beyond first 14 days of life. After extensive evaluation a diagnosis of either biliary atresia or neonatal hepatitis is made in 70-80% of cases. Neonatal hepatitis and biliary atresia form a pathophysiologic process directed at various levels of the hepatobiliary tract. Inflammation in the bile duct epithelium may result in the sclerosis and obliteration of the bile ducts and manifest as biliary atresia. Primary hepatocellular inflammation is more likely to result in neonatal hepatitis. Half of the cases of neonatal hepatitis resolve without sequelae, while most of the biliary atresia cases require surgical intervention for repair or, ultimately, liver transplant.
新生儿胆汁淤积是指出生后14天内结合胆红素持续升高（超过总胆红素的20%）。经过广泛评估，70-80%的病例被诊断为胆道闭锁或新生儿肝炎。新生儿肝炎和胆道闭锁形成了一个针对肝胆管不同水平的病理生理过程。胆管上皮的炎症可能导致胆管硬化和闭塞，并表现为胆道闭锁。原发性肝细胞炎症更有可能导致新生儿肝炎。一半的新生儿肝炎病例可无后遗症地痊愈，而大多数胆道闭锁病例需要手术干预进行修复，最终可能需要肝移植。
