Gao Zhonghong, Xu Huibi, Huang Kaixun
Department of Chemistry, Huazhong University of Science & Technology, Wuhan, People's Republic of China.
Biol Trace Elem Res. 2002 Sep;88(3):271-9. doi: 10.1385/BTER:88:3:271.
The effect of rutin on total antioxidant status as well as on trace elements such as iron, copper, and zinc in mouse liver and brain were studied. Mice were administrated with 0.75 g/kg or 2.25 g/kg P. O. of rutin for 30 d consecutively. Following the treatment, the activity of total antioxidant status, catalase, Cu,Zn-superoxide dismutase, Mn-superoxide dismutase, zinc, copper, and iron were measured in mouse liver and brain. The results showed that rutin significantly increased the antioxidant status and Mn-superoxide dismutase activities in mouse liver, but it had no effect on these variables in the brain. Treatment with a higher concentration of rutin significantly decreased catalase activity and iron, zinc, and copper contents in mouse liver; it also resulted in a slower weight gain for the first 20 d. These results indicate that rutin taken in proper amount can effectively improve antioxidant status, whereas at an increased dosage, it may cause trace element (such as iron, zinc, and copper) deficiencies and a decrease in the activities of related metal-containing enzymes.
研究了芦丁对小鼠肝脏和大脑中总抗氧化状态以及铁、铜和锌等微量元素的影响。小鼠连续30天口服0.75 g/kg或2.25 g/kg的芦丁。处理后，测定小鼠肝脏和大脑中总抗氧化状态、过氧化氢酶、铜锌超氧化物歧化酶、锰超氧化物歧化酶、锌、铜和铁的活性。结果表明，芦丁显著提高了小鼠肝脏中的抗氧化状态和锰超氧化物歧化酶活性，但对大脑中的这些变量没有影响。用较高浓度的芦丁处理显著降低了小鼠肝脏中的过氧化氢酶活性以及铁、锌和铜含量；在前20天还导致体重增加缓慢。这些结果表明，适量摄入芦丁可有效改善抗氧化状态，而剂量增加时，可能会导致微量元素（如铁、锌和铜）缺乏以及相关含金属酶的活性降低。
