来自软毛拉坦尼（Lithraea molleoides）的杀线虫亚烷基间苯二酚

Nematicidal alkylene resorcinols from Lithraea molleoides.

作者信息

Valcic Susanne, Wächter Gerald A, Eppler C Mark, Timmermann Barbara N

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson 85721-0207, USA.

出版信息

J Nat Prod. 2002 Sep;65(9):1270-3. doi: 10.1021/np020068n.

DOI:10.1021/np020068n

PMID:12350145

Abstract

Four new alkylene resorcinols, (Z,Z)-5-(trideca-4,7-dienyl)resorcinol (1), (Z,Z,Z)-5-(trideca-4,7,10-trienyl)resorcinol (2), (Z,Z,E)-5-(trideca-4,7,10-trienyl)resorcinol (3), and (Z)-5-(trideca-4-enyl)resorcinol (4), were isolated from the MeOH-CH(2)Cl(2) extract of Lithraea molleoides. The structures of these compounds were determined by one- and two-dimensional NMR including selective decoupling experiments. In vitro all four compounds showed strong paralyzing effects on the nematode Caenorhabditis elegans at concentrations between 6 and 50 microg/mL, whereas the activity of compounds 1 and 2 against the nematode Trichostrongylus colubriformis was less pronounced and no activity against this nematode was observed for compounds 1-4 in a rodent model.

摘要

从毛叶木兰的甲醇 - 二氯甲烷提取物中分离出四种新的亚烷基间苯二酚，即(Z,Z)-5-(十三碳-4,7-二烯基)间苯二酚(1)、(Z,Z,Z)-5-(十三碳-4,7,10-三烯基)间苯二酚(2)、(Z,Z,E)-5-(十三碳-4,7,10-三烯基)间苯二酚(3)和(Z)-5-(十三碳-4-烯基)间苯二酚(4)。这些化合物的结构通过一维和二维核磁共振（包括选择性去耦实验）确定。在体外，所有四种化合物在6至50μg/mL的浓度下对秀丽隐杆线虫均表现出强烈的麻痹作用，而化合物1和2对蛇形毛圆线虫的活性则不太明显，并且在啮齿动物模型中未观察到化合物1 - 4对该线虫有活性。