Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.

作者信息

Zou Kun, Zhu Shu, Meselhy Meselhy R, Tohda Chihiro, Cai Shaoqing, Komatsu Katsuko

机构信息

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan.

出版信息

J Nat Prod. 2002 Sep;65(9):1288-92. doi: 10.1021/np0201117.

Four new dammarane-type saponins (1-4), named yesanchinosides G-J, together with nine ginsenosides (5-13) were isolated from Ye-Sanchi, the underground part of Panax japonicus collected in the south of Yunnan Province, China. Their structures were elucidated on the basis of spectroscopic and chemical methods. Ginsenosides Rb(1) and Rb(3) and notoginsenosides R(4) (6) and Fa (7) showed significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.