Elving G Jolanda, Van Weissenbruch Ranny, Busscher Henk J, Van Der Mei Henny C, Albers Frans W J
Department of Biomedical Engineering, University of Groningen, The Netherlands.
Laryngoscope. 2002 Sep;112(9):1680-3. doi: 10.1097/00005537-200209000-00028.
To establish a relationship between voice prosthetic lifetime in laryngectomized patients and the irradiation dose applied to the neck node levels (field of the neck) in which the major salivary glands are partially included. Furthermore, a possible relationship between voice prosthetic lifetime and the irradiation dose applied to the primary tumor site was studied.
A retrospective analysis was performed on 101 patients after laryngectomy.
The records of 101 patients who underwent total laryngectomy between January 1993 and November 1999 at the Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands, were analyzed. The following parameters were obtained: age, sex, radiotherapy, radiation fields, irradiation dose per field, tumor site, TNM classification, and valve insertion.
Irradiation to extensive neck fields, including the submandibular glands, did not influence the voice prosthetic lifetime after laryngectomy. However, primary tumor doses exceeding 60 Gray significantly shortened the mean voice prosthetic lifetime per patient.
This study identified an association between radiation on the primary tumor site with a dose equal to or more than 60 Gray and limited lifetimes of voice prostheses.
在喉切除患者中建立语音假体使用寿命与颈部淋巴结区域（颈部野）照射剂量之间的关系，其中主要唾液腺部分包含在该区域内。此外，还研究了语音假体使用寿命与原发肿瘤部位照射剂量之间可能存在的关系。
对101例喉切除术后患者进行回顾性分析。
分析了1993年1月至1999年11月在荷兰格罗宁根大学医学中心耳鼻咽喉科接受全喉切除术的101例患者的记录。获取了以下参数：年龄、性别、放疗、照射野、每个野的照射剂量、肿瘤部位、TNM分类和瓣膜植入情况。
对包括下颌下腺在内的广泛颈部野进行照射，并不影响喉切除术后语音假体的使用寿命。然而，原发肿瘤剂量超过60格雷会显著缩短每位患者的平均语音假体使用寿命。
本研究确定了原发肿瘤部位接受等于或超过60格雷的放疗与语音假体使用寿命有限之间存在关联。
