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232 例患者连续 13 年的喉切除术后假体嗓音康复结果。

Postlaryngectomy prosthetic voice rehabilitation outcomes in a consecutive cohort of 232 patients over a 13-year period.

机构信息

Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Biometrics Department, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

出版信息

Head Neck. 2019 Mar;41(3):623-631. doi: 10.1002/hed.25364. Epub 2019 Jan 7.

DOI:10.1002/hed.25364
PMID:30614644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6590326/
Abstract

BACKGROUND

With the increasing necessity for total laryngectomy (TL) after prior (chemo)radiotherapy, prosthetic vocal rehabilitation outcomes might have changed.

METHODS

Retrospective cohort study including all patients laryngectomized between 2000 and 2012 with a voice prosthesis (VP) in the Netherlands Cancer Institute.

RESULTS

Median device lifetimes of the standard Provox2 and Vega VPs are 63 and 66 days, respectively, and for the problem-solving ActiValve Light and Strong VPs 143 and 186 days, respectively. In multivariable analysis, salvage TL and TL for a dysfunctional larynx (compared to primary TL) were associated with a shorter device lifetime. Almost half of the patients (48%) experienced tracheoesophageal puncture tract-related problems, and this concerned 12% of all VP replacements.

CONCLUSIONS

Compared to historical cohorts, device lifetimes of regular Provox2 and Vega voice prostheses have decreased. Complications are not occurring more frequently but affect more patients. Nevertheless, the clinical reliability and validity of prosthetic voice rehabilitation is still sound.

摘要

背景

由于先前（放化疗）后全喉切除术（TL）的必要性增加，假体发声康复的效果可能已经发生了变化。

方法

回顾性队列研究包括 2000 年至 2012 年间在荷兰癌症研究所使用声门假体（VP）的所有患者。

结果

标准 Provox2 和 Vega VP 的中位装置寿命分别为 63 天和 66 天，而问题解决型 ActiValve Light 和 Strong VP 的寿命分别为 143 天和 186 天。多变量分析表明，挽救性 TL 和因功能失调的喉而进行的 TL（与原发性 TL 相比）与装置寿命较短相关。近一半的患者（48%）经历了气管食管穿刺道相关问题，这占所有 VP 更换的 12%。

结论

与历史队列相比，常规 Provox2 和 Vega 语音假体的使用寿命已经缩短。并发症并没有更频繁地发生，而是影响了更多的患者。然而，假体发声康复的临床可靠性和有效性仍然存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df1/6590326/4e480e4249c5/HED-41-623-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df1/6590326/402c6d7c9910/HED-41-623-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df1/6590326/4e480e4249c5/HED-41-623-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df1/6590326/402c6d7c9910/HED-41-623-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df1/6590326/4e480e4249c5/HED-41-623-g002.jpg

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本文引用的文献

1
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J BUON. 2017 May-Jun;22(3):807-811.
2
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JAMA Otolaryngol Head Neck Surg. 2017 Jan 1;143(1):65-71. doi: 10.1001/jamaoto.2016.2771.
3
Factors influencing the longevity and replacement frequency of Provox voice prostheses.影响Provox语音假体使用寿命和更换频率的因素。
One hundred fifty years of total laryngectomies.
全喉切除术的150年历程。
Front Oncol. 2024 Jun 10;14:1351549. doi: 10.3389/fonc.2024.1351549. eCollection 2024.
4
Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020.喉癌和下咽癌行喉切除术的肿瘤学和功能结局：2001 年至 2020 年德国的一项基于人群的分析。
Sci Rep. 2024 Apr 2;14(1):7761. doi: 10.1038/s41598-024-58423-x.
5
Analysis of durability and replacement of vocal prostheses in total laryngectomy patients at a head and neck surgery referral center.头颈部外科转诊中心全喉切除术后患者的人工发声器耐用性和更换分析。
Eur Arch Otorhinolaryngol. 2024 Jan;281(1):351-357. doi: 10.1007/s00405-023-08180-w. Epub 2023 Sep 30.
6
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J Pers Med. 2023 Jun 29;13(7):1064. doi: 10.3390/jpm13071064.
7
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8
Prosthetic voice rehabilitation after laryngoesophagectomy: surgical and functional outcomes.喉咽切除术后的假体嗓音康复：手术和功能结果。
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9
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4
Trends in treatment and survival for advanced laryngeal cancer: A 20-year population-based study in The Netherlands.晚期喉癌的治疗与生存趋势：荷兰一项基于人群的20年研究。
Head Neck. 2016 Apr;38 Suppl 1:E1247-55. doi: 10.1002/hed.24200. Epub 2015 Aug 28.
5
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10
Role of reflux in tracheoesophageal fistula problems after laryngectomy.反流在喉切除术后气管食管瘘问题中的作用。
Ann Otol Rhinol Laryngol. 2010 Nov;119(11):719-28.