Kobayashi Minatsu, Tsubono Yoshitaka, Sasazuki Shizuka, Sasaki Satoshi, Tsugane Shoichiro
Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa, Japan.
Int J Cancer. 2002 Nov 1;102(1):39-44. doi: 10.1002/ijc.10659.
The association between vegetables and fruit consumption and gastric cancer risk was investigated in a population-based prospective study in 4 public health center areas in Japan. Dietary and other exposure data were obtained in 1990 from a cohort of 19,304 men and 20,689 women with a self-administered questionnaire. After 10 years of follow-up, a total of 404 cases of gastric cancer were documented among them. After adjustment for age, gender, areas and other potential confounding factors and after exclusion of the cases diagnosed in first and second follow-up years, the relative risk associated with intake 1 or more days per week compared to less than 1 day per week was 0.64 (95% CI 0.45-0.92) for yellow vegetable, 0.48 (95% CI 0.25-0.89) for white vegetable and 0.70 (95% CI 0.49-1.00) for fruit. Relative risks associated with quintile of total vegetable consumption were 1.00, 0.86, 0.75, 0.90 and 0.75 (p for trend = 0.17). In the differentiated type of gastric cancer, the association became clearer: 1.00, 0.96, 0.78, 0.88 and 0.53 (p for trend = 0.03). This prospective study suggests that vegetable and fruit intake, even in low amounts, is associated with a lower risk of gastric cancer. Although no striking differences in the association were seen between cardia and noncardia cancer, an inverse association was higher in differentiated rather than in undifferentiated types of gastric cancer.
在日本4个公共卫生中心地区开展的一项基于人群的前瞻性研究中，对蔬菜和水果摄入量与胃癌风险之间的关联进行了调查。1990年通过一份自填式问卷，从19304名男性和20689名女性队列中获取了饮食及其他暴露数据。经过10年的随访，他们当中共记录了404例胃癌病例。在对年龄、性别、地区及其他潜在混杂因素进行校正后，且排除在首次和第二次随访年份诊断出的病例后，与每周摄入1天或更多天相比，每周摄入少于1天的黄色蔬菜的相对风险为0.64（95%可信区间0.45 - 0.92），白色蔬菜为0.48（95%可信区间0.25 - 0.89），水果为0.70（95%可信区间0.49 - 1.00）。与蔬菜总摄入量五分位数相关的相对风险分别为1.00、0.86、0.75、0.90和0.75（趋势p值 = 0.17）。在分化型胃癌中，这种关联变得更明显：1.00、0.96、0.78、0.88和0.53（趋势p值 = 0.03）。这项前瞻性研究表明，即使少量摄入蔬菜和水果也与较低的胃癌风险相关。尽管在贲门癌和非贲门癌之间未观察到关联上的显著差异，但在分化型而非未分化型胃癌中，负相关更高。
