水果和蔬菜摄入量与胃癌风险的关系：队列研究的全面更新系统评价和剂量反应荟萃分析
Fruit and vegetable intake in relation to gastric cancer risk: A comprehensive and updated systematic review and dose-response meta-analysis of cohort studies.
作者信息
Naemi Kermanshahi Mohammad, Safaei Ehsan, Tutunchi Helda, Naghshi Sina, Mobarak Sara, Asadi Masoomeh, Sadeghi Omid
机构信息
Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Front Nutr. 2023 Feb 6;10:973171. doi: 10.3389/fnut.2023.973171. eCollection 2023.
BACKGROUND
Since the release of previous meta-analyses, some studies on the associations between fruit and vegetable intake with gastric cancer risk have been published. Therefore, we aimed to update the previous meta-analyses on these associations by including recently published studies as well as considering the main limitations of those meta-analyses.
METHODS
A comprehensive search was conducted in online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar to detect relevant prospective cohort studies published up to October 2021. Summary relative risks (RRs) were estimated using a random-effects model.
RESULTS
Overall, 17 articles containing 18 prospective studies with a total sample size of 1,527,995 participants, aged between 18 and 90 years, were included in the current meta-analysis. During the follow-up periods ranging between 4.5 and 21 years, 8,477 cases of gastric cancer were diagnosed. A higher intake of total fruit [RR: 0.87, 95% confidence interval (CI): 0.80 to 0.94, = 0%] and total fruit and vegetable (RR: 0.75, 95% CI: 0.61 to 0.93, = 55.2%) were associated with a lower risk of gastric cancer. For total vegetable intake, a significant inverse association was found among the studies that controlled their analysis for energy intake. Based on the linear dose-response analysis, each 100 g/day increase in total fruit intake (Pooled RR: 0.95, 95% CI: 0.90 to 0.99, = 49%) and 200 g/day increase in total fruit and vegetable intake (RR: 0.94, 95% CI: 0.88 to 0.99, = 37.6%) were associated with a 5 and 6% lower risk of gastric cancer, respectively.
CONCLUSION
Fruit and vegetable consumption has a protective association with gastric cancer risk.
背景
自之前的荟萃分析发布以来，一些关于水果和蔬菜摄入量与胃癌风险之间关联的研究已发表。因此，我们旨在通过纳入最近发表的研究并考虑那些荟萃分析的主要局限性，来更新之前关于这些关联的荟萃分析。
方法
在包括PubMed、Scopus、ISI Web of Science和谷歌学术在内的在线数据库中进行全面检索，以检测截至2021年10月发表的相关前瞻性队列研究。使用随机效应模型估计汇总相对风险（RRs）。
结果
总体而言，本荟萃分析纳入了17篇文章，其中包含18项前瞻性研究，总样本量为1,527,995名参与者，年龄在18至90岁之间。在4.5至21年的随访期内，共诊断出8477例胃癌病例。较高的总水果摄入量[RR：0.87，95%置信区间（CI）：0.80至0.94，I² = 0%]以及总水果和蔬菜摄入量（RR：0.75，95%CI：0.61至0.93，I² = 55.2%）与较低的胃癌风险相关。对于总蔬菜摄入量，在对能量摄入进行分析控制的研究中发现了显著的负相关。基于线性剂量反应分析，总水果摄入量每增加100克/天（汇总RR：0.95，95%CI：0.90至0.99，I² = 49%）和总水果和蔬菜摄入量每增加200克/天（RR：0.94，95%CI：0.88至0.99，I² = 37.6%）分别与胃癌风险降低5%和6%相关。
结论
水果和蔬菜消费与胃癌风险存在保护性关联。
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