Easter Stephen S, Malicki Jarema J
Dept. of Molecular, Cellular, and Developmental Biology, University of Michigan, 830N. University Ave., Ann Arbor, Michigan 48109-1048, USA.
Results Probl Cell Differ. 2002;40:346-70. doi: 10.1007/978-3-540-46041-1_17.
In this review, we have attempted to cover all the major points of zebrafish eye development, and have found that, for the most part, it has much in common with other eyes, in both vertebrates and the fly. In addition to the confirmation and extension of earlier studies, however, the work on zebrafish has provided some new insights that should be assessed for their applicability to the development of other vertebrates. Among these are the modulated cellular proliferation in the optic vesicle, the complex spatiotemporal pattern of central retinal neurogenesis, the emergence of spatial order among the photoreceptors, the genetic controls of cell fates, and the genetic mechanisms underlying retinal stratification. Substantial though it is, this contribution will grow rapidly in the next few years as the advances of zebrafish genetics are accelerated by progress of genomics, especially the zebrafish genome project.
在本综述中，我们试图涵盖斑马鱼眼睛发育的所有要点，并发现，在很大程度上，它与脊椎动物和果蝇的其他眼睛有许多共同之处。然而，除了对早期研究的确认和扩展之外，斑马鱼研究工作还提供了一些新见解，这些见解的适用性应针对其他脊椎动物的发育进行评估。其中包括视泡中受调节的细胞增殖、视网膜中央神经发生的复杂时空模式、光感受器之间空间秩序的出现、细胞命运的遗传控制以及视网膜分层的遗传机制。尽管这一贡献很大，但随着基因组学的进展，尤其是斑马鱼基因组计划的推进加速了斑马鱼遗传学的发展，在未来几年它将迅速增长。
